Gene Expression Group
Thomas Perlmann Ph.D., Professor, Member
The development of the CNS is dependent on signaling pathways that converge on specifically expressed transcription factors. We are interested in mechanisms important for how stem cells develop into specific neuronal types. Our research has focused on transcription factors and signaling pathways involved in the development of dopamine neurons. Understanding how neural stem cells differentiate has implications for cell replacement therapy in Parkinson's disease. Moreover, the elucidation of how normal stem cells differentiate in the developing CNS relates to the processes that are abnormally regulated in cancer initiating stem cells.
The Group
- Dahl, Lina Postdoctoral Fellow
- Joodmardi, Eliza Senior Technician
- Kee, Nigel Ph.D. Student
- Laguna, Ariadna Postdoctoral Fellow
- Lundén-Miguel, Hilda Technical Research Assistant
- Mong, Jamie Ph.D. Student
- Nobre, André Postdoctoral Fellow
- Panman, Lia Postdoctoral Fellow
- Papathanou, Maria Postdoctoral Fellow
- Tiklova, Katarina Postdoctoral Fellow
- Volakakis, Nick Research Associate
Selected Publications
- Malewicz, M., Kadkhodaei, B., Kee, N. Volakakis, N. Hellman, U., Viktorsson, K., Leung, S.Y., Chen, B., Lewensohn, R., van Gent, D.C., Chen, D.J., Perlmann, T. (2011) "Essential Role for DNA-PK-mediated Phosphorylation of NR4A Nuclear Orphan Receptors in DNA Double Strand Break Repair" Genes Dev 25, 2031-2040
- Deng, Q., Andersson, E., Hedlund, E., Alekseenko, Z., Coppola, E. Panman, L. Millonig, J.H. Brunet, J.-F., Ericson, J., Perlmann, T. (2011) "Specific and Integrated Roles of Lmx1a, Lmx1b and Phox2a in Ventral Midbrain Development" Development 138, 3399-3408
- Panman, L., Andersson, L., Alekseenko, Z., Hedlund, E., Kee, N., Mong, J., Uhde, C.W., Deng, Q., Sandberg, R., Stanton, L.W., Ericson, J., Perlmann, T. (2011) " Transcription factor-induced lineage selection of stem cell-derived neural progenitor cells" Cell Stem Cell 8, 663-675
- Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S.-I., Sumi-Ichinose, C., Nomura, T., Metzger, D., Chambon, P., Lindqvist, E., Larsson, N.G., Olson, L., Björklund, A., Ichinose, H., and Perlmann, T. (2009) "Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons" J. Neurosci. 29, 15923-15932
- Friling, S, Andersson, E, Thompson, L.H., Jönsson, M.E., Hebsgaard, J.B., Nanou, E., Alekseenko, Z., Marklund, U., Kjellander, S., Volakakis, N., Hovatta, O., El Manira, A., Björklund, A., Perlmann, T.*, and Ericson, J.* (2009) "Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells" Proc. Natl. Acad. Sci., U.S.A 106, 7613-1618, *Co-senior authors
- Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B. Perlmann, T.* and Ericson, J.* (2006) "Identification of intrinsic determinants of midbrain dopamine neurons" Cell 124, 393-345, *Co-senior authors
